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Tolfenamic Acid

Tolfenamic Acid

Quick Details P roduct name: Tolfenamic acid 13710-19-5 CAS No.: 13710-19-5 Other Names: N-(3-Chloro-ortho-tolyl) anthranilic acid MF: C14H12ClNO2 EINECS No.: 237-264-3 Place of Origin: hubei, China (Mainland) Type: Antipyretic Analgesics and NSAIDs Grade Standard: Medicine Grade Brand Name:...

Products Specifications:

Quick Details
Product name: Tolfenamic acid 13710-19-5

CAS No.: 13710-19-5

Other Names: N-(3-Chloro-ortho-tolyl) anthranilic acid

MF: C14H12ClNO2

EINECS No.: 237-264-3

Place of Origin: hubei, China (Mainland)

Type: Antipyretic Analgesics and NSAIDs

Grade Standard: Medicine Grade

Brand Name: Dahua

Purity: 99.0~101.0%

storage temp.: Refrigerator


SupplyAbility
200 Ton/Tons per Month


Packaging & Delivery
Packaging Details
Our regular package is 25 kg/drum.

Port: Shanghai

Lead Time: Within 7-10 days after receipt of your payment.


Specification of Tolfenamic acid 13710-19-5

Inspect Item

Specification

Results

Appearance

White or slightly yellow, crystalline powder

Conforms

Solubility

Practically insoluble in water, soluble in dimethylformamide, sparingly soluble in ethanol and in methylene chloride

Conforms

Identification

A. Light absorption: the ratio of the absorbance measured at the maximum at 286nm to that maximum at 345nm should be 1.2 to 1.4

Conforms

B. IR absorption spectrophotometry should be conformed

1.2

C. TLC chromatography (245nm) should be conformed

Conforms

Melting point

210~214℃

212.1~212.6℃

Related substances

Impurity A<0.1%;Impurity B<0.05%

Conforms

Any other impurity<0.1%

Conforms

Total impurity<0.5%

Conforms

Copper

Not more than 10ppm

Conforms

Loss on drying

Not more than 0.5%

0.20%

Sulphated ash

Not more than 0.1%

<0.1%

Assay (basis on dry)

99.0~101.0%

99.70%

Conclusion

The results conforms with EP6.0 standards


Description:
Tolfenamic acid (Clotam) is a member of the anthranilic acid derivatives (or fenamate) class of NSAID drugs discovered by scientists at Medica Pharmaceutical Company in Finland. Like other members of the class, it is a COX inhibitor and prevents formation of prostaglandins.


Tolfenamic acid

图片55_副本.jpg

Clinical data

AHFS/Drugs.com

International Drug Names

Routes of
administration

oral

ATC code

M01AG02 (WHO)

Legal status

Legal status

AU: S4 (Prescription only)

Identifiers

IUPAC name

2-[(3-chloro-2-methylphenyl)amino]benzoic acid)[1]

CAS Number

13710-19-5 

PubChem CID

610479

ChemSpider

530683 

UNII

3G943U18KM

KEGG

D01183 

ChEBI

CHEBI:32243 

ChEMBL

CHEMBL121626 

ECHA InfoCard

100.033.862 

Chemical and physical data

Formula

C14H12ClNO2

Molar mass

261.707 g/mol

3D model (JSmol)

Interactive image

SMILES

Clc2cccc(Nc1ccccc1C(=O)O)c2C


InChI

InChI=1S/C14H12ClNO2/c1-9-11(15)6-4-8-12(9)16-13-7-3-2-5-10(13)14(17)18/h2-8,16H,1H3,(H,17,18)

Key:YEZNLOUZAIOMLT-UHFFFAOYSA-N

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FUNCTION:
It is used in the UK as a treatment for migraine. It is generally not available in the US.] It is available in some Asian, Latin American and European countries as a generic drug for humans and for animals.

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