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Rufinamide

Rufinamide

Quick Details CAS No.: 106308-44-5 Other Names: Rufinamide MF: C10H8F2N4O EINECS No.: 200-659-6 Place of Origin: wuhan, China (Mainland) Type: Antibiotic and Antimicrobial Agents Grade Standard: Medicine Grade Brand Name: Dahua Model Number: USP 39 Purity: 99.9% Test Standard: EP...

Products Specifications:

Quick Details 

CAS No.: 106308-44-5

Other Names: Rufinamide

MF: C10H8F2N4O

EINECS No.: 200-659-6

Place of Origin: wuhan, China (Mainland)

Type: Antibiotic and Antimicrobial Agents

Grade Standard: Medicine Grade

Brand Name: Dahua

Model Number: USP 39

Purity: 99.9%

Test Standard: EP 9.0/USP39/BP2015

Content: 99.0% to 101.0%

Test method: HPLC-ESI-MS

Water: 0.5% Max.

Sulfated ash: 0.1% Max.

Heavy metals: 10ppm Max

Total Impurity: 0.5% Max.

Total plate count: ≤1000cfu/g

Yeast and Moulds: ≤100cfu/g


SupplyAbility
100 Ton/Tons per Year


Packaging & Delivery
Packaging Details
25kgs/Drum; 5kgs/Tin&10kgs/Carton
Port
Any main port of China
Lead Time: 10 Days


Product Description

Product:

Rufinamide

Cas No.:

106308-44-5

Molecular Formula:

C10H8F2N4O

Specification:

99%

Structure:

图片102_副本.jpg


Item

Standard

Test Results

Identification

A.H-NMR:Comply with the structure

Complies

B.LC-MS:Comply with the structure

Complies

C.The IR spectrum of sample should be identical with that of reference standard;

Complies

D.HPLC-ESI-MS
The retention time of the major peak in the chromatogram of the Assay preparation corresponds to that in the chromatogram of the Standard preparation, as obtained in the Assay.

Complies

Crystallinity

meets the requirements.

Complies

Loss on drying

≤2.0%

0.19%

Heavy metals

≤10 ppm

<10ppm

Water

≤1.0%

0.1%

Sulphated ash

≤0.5%, determined on 1.0 g.

0.009%

Related substances

Unspecified impurities: for each impurity

≤0.10%

<0.10%

Total Impurity

≤0.5%

0.18%

Purity

≥99.0%

99.7%

Assay

99.0%~101.0% (anhydrous substance).

99.8%

Microbiological Analysis

Total plate count

≤1000cfu/g

Complies

Yeast and Moulds

≤100cfu/g

Complies

E. Coli.

Absent

Negative

Salmonella

Absent

Negative

S.aureus

Absent

Negative

Storage

Preserve in well-closed, light-resistant and airtight containers.

Complies


Our Services
a) Free sample can be supplied.
b) Guide our clients by professinal knowledge and teach them how to use our product after sales
c) Accpet SGS,BV any other third-party inspection before loading
d) High quality best price Guaranteed


FAQ
Why do you choose Dideu Industries as your partner?
A) High quality can be guaranteed. Dideu Industries since 1975 are reputed chemical manufacturer and are Certified by ISO,GMP,FDA and have CEP/COS certification.Free sample can be arranged before shipment and SGS,BV and other third party inspection company are accepted before loading.For regular customers, we accept L/C 180 Days, D/P,D/A payment term. If there is any quality problem after goods arrive. Dideu Industries will do fully payment refund.
B) Best price can be guaranteed. As Dideu Industries are integrated pharmaceuticals and chemicals producer the production cost can be controlled and price will be definitely more competitive than China trading companies.
C) Professional enginners from Dideu Industries will give professional usage guide and services after sales.
D) Dideu Industries work 7×24 hours and your request will be processed by our professional staff in different shift period.


Function:

Rufinamide is an anticonvulsant medication. It is used in combination with other medication and therapy to treat Lennox–Gastaut syndrome and various other seizure disorders. Rufinamide, a triazole derivative, was developed in 2004 by Novartis Pharma, AG, and is manufactured by Eisai.
Rufinamide was approved by the US Food and Drug Administration on November 14, 2008 as adjunctive treatment of seizures associated with Lennox-Gastaut syndrome in children 4 years and older and adults. Its official FDA-approved labeling does not mention use in the treatment of partial seizures inasmuch as clinical trials submitted to the FDA were marginal. However, several recent clinical trials suggest that the drug has efficacy for partial seizures It is marketed under the brand name Banzel. It is also marketed in the European Union under the brand name Inovelon.
The mechanism of action of rufinamide is unknown. There is some evidence that rufinamide can modulate the gating of voltage-gated sodium channels, a common target for antiepileptic drugs. A recent study indicates subtle effects on the voltage-dependence of gating and the time course of inactivation in some sodium channel isoforms that could reduce neuronal excitability.However, this action cannot explain the unique spectrum of activity of rufinamide.

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