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High Purity 99% Metronidazole

High Purity 99% Metronidazole

Model NO.: PL202
Usage Mode: Injection
State: Liquid
Type: Inorganic Chemicals
Specification: 500mg/100ml

Products Specifications:

Basic Info

● Model NO.: PL202

● Usage Mode: Injection

● State: Liquid

● Type: Inorganic Chemicals

● Specification: 500mg/100ml

● Application: Internal Medicine

● Suitable for: Elderly, Adult

● Shape: Injection

● Pharmaceutical Technology: Chemical Synthesis

● Origin: China


Product Description
In addition to anti trichomonas and amebic protozoa, it has been widely used in recent years to combat anaerobic infection. Nitro, which is reduced to amino in anaerobic environment, shows no effect on anaerobic bacteria, and is not effective for aerobic bacteria or facultative aerobic bacteria. There are good antibacterial effects on the following Anaerobes: (1) Pseudomonas, including bacilli fragile; 2. Clostridium; 3. Clostridium, including tetanus; (4) true bacilli; 5, digestive and Streptococcus. Oral absorption of good (>80%), oral 250mg or 500mg, 1 ~ 2 hours of serum drug concentration reached a peak of 6 g/ml and 12 g/ml respectively. 


Intravenous drip of this product 15mg/kg, after every 6 hours drip 7.5mg/kg, plasma drug concentration reached steady state peak concentration of 25 mu g/ml, valley concentration can reach 18 g/ml. This product is widely distributed in the body and can enter the pus of saliva, milk and liver abscess, and can also enter the cerebrospinal fluid (50% of the normal human cerebrospinal fluid can reach the blood). In vivo, it is metabolized by side chain oxidation or combined with glucuronic acid, and 20% of them are not metabolized. Its metabolites also have certain activity. A large amount of metronidazole and its metabolites were excreted by urine (60% to 80% of the total), and a small amount was excreted by feces (6% ~ 15%). T1/2 is about 8 hours.


Indication
It is mainly used for the treatment or prevention of systemic or local infections caused by the aforementioned anaerobes, such as the abdominal, digestive, female genital, lower respiratory, skin and soft tissues, bone and joint. It is also effective for septicemia, endocarditis, meningeal infection, and antibiotic induced colitis. Tetanus is often used in combination with Tetanus Antitoxin (TAT). It can also be used for oral anaerobe infection.


Product Name:

Metronidazole

Synonyms:

1-(2-Hydroxy-1-ethyl)-2-methyl-5-nitroimidazole;1-(2-hydroxyethyl)-2-methyl-5-nitroimidazole;1-(beta-Hydroxyethyl)-2-methyl-5-nitroimidazole;1-(beta-Oxyethyl)-2-methyl-5-nitroimidazole;1H-Imidazole-1-ethanol, 2-methyl-5-nitro-;1H-Imidazole-1-ethanol,2-methyl-5-nitro-;1-Hydroxyethyl-2-methyl-5-nitroimidazole;2-(2-Methyl-5-nitro-1H-imidazol-1-yl)ethanol

CAS:

443-48-1

MF:

C6H9N3O3

MW:

171.15

EINECS:

207-136-1

Product Categories:

Active Pharmaceutical Ingredients;API's;Peptide Synthesis/Antibiotics;Heterocycles;Intermediates & Fine Chemicals;Pharmaceuticals;FLAGYL;antibiotic

Mol File:

443-48-1.mol



Metronidazole Chemical Properties

Safety Information


mp

159-161 °C(lit.)

storage temp.

2-8°C

solubility

acetic acid: 0.1 M, clear, faintly yellow

form

crystalline

Water Solubility

<0.1 g/100 mL at 20 ºC

Merck

6157

Stability:

Stable. Incompatible with strong oxidizing agents.

NIST Chemistry Reference

Metronidazole(443-48-1)

EPA Substance Registry System

1H-Imidazole-1-ethanol, 2-methyl-5-nitro-(443-48-1)


Hazard Codes

Xn,T

Risk Statements

40-46-45

Safety Statements

36/37-45-53

WGK Germany

3

RTECS

NI5600000

F

8

HS Code

29332990

Hazardous Substances Data

443-48-1(Hazardous Substances Data)

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