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Anti-Inflammatory Steroids Dexamethasones

Anti-Inflammatory Steroids Dexamethasones

Model NO.: 55203-24-2
Betamethasone Mf: C22h28fo8p2na
Betamethasone MW: 516.45
Melting Point: +118 ~ +126 .
Specific Rotation: +34~ +38

Products Specifications:

Basic Info

Model NO.: 55203-24-2
Betamethasone Mf: C22h28fo8p2na
Betamethasone MW: 516.45
Melting Point: +118 ~ +126 .
Specific Rotation: +34~ +38
Loss on Drying: <1.0%
Organic Volatile Impurities: <850ppm
Dosage: 50mg Every Day
Storage Temp: 2-8 Centigrade
Usage: Oral Liquid or Tablet
Export Markets: Global
Trademark: ZJY
Transport Package: Discreet Package
Specification: White Powder
Origin: China
HS Code: 3001200010


Product Description

In 1958, dexamethasone was synthesized by Arth and Oliveto respectively, and dexamethasone sodium phosphate was produced by Merck & Co. in 1960. More than 12 kinds of dexamethasone derivatives have been listed.

The chemical structure of dexamethasone is the introduction of fluorine atoms in the B ring 9 alpha of prednisolone and the introduction of methyl in the D Ring 16 alpha position; 9 alpha fluorine and 16 alpha methyl all enhance its anti-inflammatory activity significantly, while 16 alpha methylate significantly reduces the sodium retention side effect of dexamethasone. The clinical bioequivalent dose ratio of dexamethasone and prednisolone was 0.75:5, and the biological half-life was 36-54 hours, which was classified as long-acting glucocorticoid.

Dexamethasone, like other glucocorticoids, is widely used in various diseases, such as autoimmune diseases, allergies, inflammation, asthma, and Department of Dermatology and Ophthalmology, with the pharmacological effects of anti-inflammatory, anti endotoxin, immunosuppressive, anti shock and stress response. Dexamethasone sodium phosphate injection is a necessary emergency medicine for rescuing the dying patients. In the past ten years, clinicians have applied dexamethasone sodium phosphate in the treatment and prevention of drug allergies caused by various Chinese and Western medicine and the treatment of fever caused by the virus, which has made the clinical use of dexamethasone increasing year by year. The largest dexamethasone market in the world.


COA

Appearance

White crystalline powder

Chromatographic purity

Any individual impurity not more than 1.0%
Total impurities not more than 2.0%

0.3%
1.0%

Loss on drying

Not more than 0.5%

0.3%

Residue on ignition

Not more than 0.2%

0.07%

Residual solvents

Methanol≤3000ppm
Methylene Chloride≤600ppm
Chloroform≤60ppm
Tetrahydrofuran≤720ppm

335ppm
Not detect out
Not detect out
Not detect out

Assay

Between 97.0% and 102.0%

98.9%

Micronixation

90% not more than 10 microns

90% not more than 10 aicrons

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